What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Type 2 diabetes mellitus and coronary artery stenosis (n=303). Intervention: Atherogenic Index of Plasma (AIP) vs. Lower AIP levels. Primary outcome: Obstructive coronary artery disease (luminal stenosis ≥50%) (OR 3.93, 95% CI 1.70-9.62, p=0.001).

What question did this study set out to answer?

This research aims to explore how the Atherogenic Index of Plasma (AIP) relates to the severity of coronary artery stenosis in individuals with type 2 diabetes mellitus.

June 24, 2026Open Access

Atherogenic index of plasma and the severity of coronary artery stenosis in patients with type 2 diabetes mellitus: a retrospective cross-sectional study

Q: What does this research mean for the field?

Higher Atherogenic Index of Plasma (AIP) levels are independently associated with more severe coronary artery stenosis in patients with type 2 diabetes mellitus, demonstrating superior discriminative ability compared to traditional lipid markers. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Resultado clave

Higher Atherogenic Index of Plasma (AIP) levels were independently associated with obstructive coronary artery stenosis (≥50%) in patients with type 2 diabetes mellitus, with an odds ratio of 3.93.

Puntos clave

This research aims to explore how the Atherogenic Index of Plasma (AIP) relates to the severity of coronary artery stenosis in individuals with type 2 diabetes mellitus.
Patients with type 2 diabetes were categorized into four groups based on AIP quartiles.
Severity of stenosis was assessed using quantitative measures; statistical analyses included correlation tests and multivariable logistic regression.
ROC curve analysis was used to evaluate the discriminative ability of AIP compared to traditional lipid markers.
AIP levels showed a significant dose-response relationship with increasing severity of coronary stenosis (P for trend <0.01).
Median AIP was higher in patients with severe stenosis (≥70%: 0.14 vs. non-obstructive: 0.05, P<0.001).
AIP was independently associated with obstructive stenosis (≥50%), with an odds ratio of 3.93 (95% CI: 1.70-9.62).

Diseño del estudio

Tipo

Cross-Sectional (n=303)

Multicéntrico

PICO estructurado

Is the Atherogenic Index of Plasma associated with the severity of coronary artery stenosis in patients with type 2 diabetes mellitus?

Población

Patients with type 2 diabetes mellitus (T2DM)

Intervención

Higher Atherogenic Index of Plasma (AIP)

Comparador

Lower Atherogenic Index of Plasma (AIP)

Resultado

Severity of coronary artery stenosissurrogate

Higher Atherogenic Index of Plasma is independently associated with more severe coronary stenosis in patients with type 2 diabetes mellitus, demonstrating superior discriminative ability compared to traditional lipid markers.

Resultado numérico

Estimación del efecto: OR 3.93 (95% CI 1.70-9.62)

valor p: p=0.001

Limitaciones

Cross-sectional study design precludes the establishment of causal relationships.
Modest sample size restricts the capacity for detailed subgroup analyses.
Exclusion of patients receiving statin therapy limits external validity.
Coronary artery stenosis was assessed using CCTA rather than more precise methods like IVUS or OCT.
Detailed information on glucose-lowering and antihypertensive medications was not systematically collected.

Resumen

Objective: This study aimed to examine the relationship between the Atherogenic Index of Plasma (AIP) and the severity of coronary artery stenosis in patients with type 2 diabetes mellitus (T2DM). Methods: (TG/HDL-C). The severity of coronary stenosis was assessed using standard quantitative measures. Participants were divided into four groups based on AIP quartiles (Q1 to Q4). Statistical analyses involved correlation tests, multivariable logistic regression, and receiver operating characteristic (ROC) curve analysis. Results: A clear dose-response trend was found between increasing AIP quartiles and greater severity of coronary stenosis (P for trend <0.01). The median AIP was significantly higher in patients with severe stenosis (≥70%) compared to those with non-obstructive disease (0.14 vs. 0.05, P<0.001). After adjusting for multiple variables, AIP remained independently associated with obstructive stenosis (≥50%), with an odds ratio of 3.93 (95% confidence interval: 1.70-9.62). The area under the ROC curve (AUC) for AIP was 0.598 (95% CI: 0.540-0.653), which was significantly better than that for LDL cholesterol (0.481, P = 0.032) and HDL cholesterol (0.384, P<0.001). Conclusion: Higher AIP levels are independently associated with more severe coronary stenosis in patients with T2DM and demonstrate superior discriminative ability compared to traditional lipid markers in this cross-sectional cohort. Therefore, AIP may be considered an adjunctive biomarker for cardiovascular risk stratification in this high-risk population, pending prospective validation.

Me gusta

Guardar

Ver artículo completo