Anisotropic Fascial Macrotracks as Active Biomechanical Waveguides and Bioelectric Control Matrices for Non-Neuronal Regenerative Signaling

This study presents a unified, non-neurological theoretical framework for systemic somatic integration, conceptualized as the Interstitial Information Control Circuit (IICC). We re-engineer the anatomical role of dense connective tissue macrotracks, modeling them as active parametric waveguides capable of real-time regulatory signaling independent of classical neural pathways. The structural substrate of this system consists of a continuous, highly conductive functional network of fascial telocytes integrated into anisotropic collagen bundles. Long-range translation of mechanical signals is achieved via low-frequency elastic shear waves. Viscoelastic attenuation inherent to the interstitial hydrogel is dynamically compensated by continuous energy pumping from skeletal muscle microtremor (8-12 Hz), which modulates macroscopic tissue pre-stress and sustains solitary wave propagation at velocities of 1. 5 to 3. 0 m/s. The advancing wavefront induces transient lateral tension in telocyte membranes, cyclically activating mechanosensitive PIEZO1 and PIEZO2 channels. The resulting localized calcium influx triggers secondary calcium-activated chloride currents (ANO1), converting transient mechanical deflections into sustained, long-lived alterations of the baseline membrane potential (Vₘem). This stable electrogenic shift propagates electrotonically via connexin-43 (Cx43) gap junctions, establishing a trans-tissue electrophoretic gradient. This bioelectric platform drives the directed electromigration of morphogens and initiates nuclear mechanotransduction via LINC-complexes, ultimately reshaping topological chromatin domains (TADs) to modulate regenerative and anti-inflammatory gene expression transcriptionally. The IICC model provides a rigorous, materialist biophysical foundation for long-range somatic conduction and systemic homeostatic coordination. Keywords: Fascial interstitium, Telocytes, PIEZO channels, Gap junctions, Tensegrity, Parametric waveguide, Bioelectric code, Non-neuronal integration, Mechanotransduction, Chromatin architecture.