Each additional guideline-recommended secondary prevention medication after MI in hemodialysis patients was associated with a 12% reduction in all-cause mortality (HR 0.88; 95% CI 0.80-0.97).
Cohort (n=1,471)
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Does the use of more guideline-recommended secondary prevention medications reduce all-cause mortality in hemodialysis patients after myocardial infarction?
The use of more evidence-based medications for secondary prevention after myocardial infarction is associated with a lower risk of all-cause mortality in hemodialysis patients.
Hazard Ratio: 0.88 (95% CI 0.8–0.97)
Background: Mortality after myocardial infarction (MI) among patients undergoing dialysis is high. However, studies investigating the use of secondary prevention medications after MI and clinical outcomes in dialysis patients are lacking. This study aimed to examine the association of the number of guideline-recommended medications (antiplatelets, β-blockers, statins and renin-angiotensin-aldosterone system inhibitors) with all-cause mortality after MI in hemodialysis (HD) patients. Methods: We conducted a nationwide cohort study of incident HD patients who were admitted for MI between 1 January 2010 and 31 December 2014 and were followed up until 31 December 2015, using Taiwan's national health insurance research database. Results: Of 1471 patients (mean age 68 years, 41. 9% women) included in the analysis, 281 (19. 1%) were treated with one cardioprotective medication, 406 (27. 6%) with two, 490 (33. 3%) with three and 294 (20%) with four. During a median follow-up of 1. 0 years, 458 (31. 1%) patients died. In a multivariable Cox model, each additional use of guideline-recommended therapies was associated with a significant 12% reduction in the risk of mortality hazard ratio HR 0. 88 95% confidence interval (CI) 0. 80-0. 97. Similar results were obtained in the analysis with the inverse probability of treatment weighting HR 0. 84 (95% CI 0. 77-0. 92) and in the propensity score-matched subcohort HR 0. 87 (95% CI 0. 77-0. 98). The decreased mortality risk was consistently observed across all subgroups. Conclusions: The use of more evidence-based medications for secondary prevention after MI was associated with a lower risk of all-cause mortality in HD patients.
Lin et al. (Sat,) conducted a cohort in Myocardial infarction in hemodialysis patients (n=1,471). Number of guideline-recommended medications (antiplatelets, β-blockers, statins, RAAS inhibitors) was evaluated on All-cause mortality (HR 0.88, 95% CI 0.80-0.97). Each additional guideline-recommended secondary prevention medication after MI in hemodialysis patients was associated with a 12% reduction in all-cause mortality (HR 0.88; 95% CI 0.80-0.97).