All heart failure guideline-directed medical therapy regimens at optimal dosages were deemed unaffordable in Venezuela, requiring between 506 and 2421 days of minimum wage to cover one month of treatment.
Cross-Sectional
All guideline-directed medical therapy regimens for heart failure are severely unaffordable in Venezuela, posing a major financial barrier to optimal care.
Background: Heart failure (HF) impacts over 56 million people worldwide, with significantly higher mortality rates in low and low-middle-income countries (LIC/LMICs). Despite the effectiveness of guideline-directed medical therapy (GDMT) for HF with reduced ejection fraction (HFrEF), its use remains limited in LIC/LMICs due to limited availability and affordability. These barriers are particularly pressing in Venezuela's context, as the country faces an ongoing crisis. Objective: Describe price and affordability of HF Guideline Directed Medical Therapy at optimal dosages in Venezuela. Methods: We conducted a cross-sectional analysis from December 2023 to January 2024, surveying prices of HF GDMT medications across 13 major pharmacy networks in Venezuela. Medications analyzed included ACE inhibitors (ACEi), angiotensin receptor blockers (ARB), beta-blockers (BB), mineralocorticoid receptor antagonists (MRA), angiotensin receptor-neprilysin inhibitors (ARNI), and sodium-glucose co-transporter 2 inhibitors (SGLT2i). Affordability was defined and calculated using the World Health Organization/Health Action International (WHO/HAI) methodology, comparing the median costs of one month of HF GDMT at optimal dosages to the lowest-paid government worker's (LPGW) daily wages. Other comparisons of price affordability were made against the mean daily salary of managers, professional and non-professional workers in the country. Results: The most expensive medication regime for HF in Venezuela was ARNI-based GDMT with a median monthly cost of 393. 81USD, followed by ARB-based GDMT and ACEi-based GDMT costing 100. 88USD and 82. 23USD respectively. meaning LPGW and elderly receiving retirement stipends would need between 506 to 2421 paid work days to cover one month of treatment at optimal dosages. Conclusion: Based on the WHO/HAI methodology all HF GDMT regimens were deemed unaffordable in Venezuela. Similar affordability challenges exist in other LIC/LMICs countries highlighting the need for global advocacy and policy action to address financial barriers to access guideline-based heart failure care.
Gebran-Chedid et al. (2025) conducted a cross-sectional in Heart failure. Heart Failure Guideline Directed Medical Therapy vs. Lowest-paid government worker's daily wages was evaluated on Affordability of HF GDMT (Affordability Ratio). All heart failure guideline-directed medical therapy regimens at optimal dosages were deemed unaffordable in Venezuela, requiring between 506 and 2421 days of minimum wage to cover one month of treatment.