A narrative review of four studies found that a fixed-dose combination of bisoprolol and amlodipine effectively reduced blood pressure and improved adherence compared to monotherapies.
Does a fixed-dose combination of bisoprolol and amlodipine improve blood pressure control and adherence compared to monotherapy in patients with hypertension?
A fixed-dose combination of bisoprolol and amlodipine is effective, safe, and improves adherence for the management of hypertension compared to monotherapy.
OBJECTIVES: Hypertension is a major cause of morbidity and mortality worldwide. Although current drug therapies can be effective, management of hypertension is closely linked to patient adherence to therapy. A fixed-dose combination (FDC) of bisoprolol and amlodipine has shown to be effective and convenient, and to significantly improve patient adherence. METHODS: This narrative review evaluates recent evidence from four studies which explore the efficacy, safety, and adherence of FDC bisoprolol and amlodipine in patients with hypertension: one observational study; two randomized clinical trials (RCTs); and one indirect comparison analysis. RESULTS: All four studies support the efficacy of FDC bisoprolol and amlodipine in the management of hypertension, highlighting clinically meaningful reductions in systolic and diastolic blood pressure (BP), and high adherence. In a large cohort study exploring FDC bisoprolol and amlodipine in daily practice, high adherence improved BP and heart rate control versus baseline. In a Phase 3 RCT, FDC bisoprolol and amlodipine demonstrated superiority over monotherapies in BP control and a positive tolerability profile, further supporting its use to manage hypertension in second line following monotherapy. In another Phase 3 RCT, the combination of bisoprolol and amlodipine led to significant BP reductions versus monotherapy with amlodipine with a comparable safety profile. Finally, in the indirect treatment comparison, a low dose combination of bisoprolol and amlodipine showed a similar decrease in systolic BP compared with a maximum dose of amlodipine. CONCLUSIONS: This review adds to growing evidence supporting the efficacy, safety, and tolerability of FDC bisoprolol and amlodipine in managing hypertension.
Gottwald‐Hostalek et al. (Thu,) conducted a review in Hypertension. Fixed-dose combination of bisoprolol and amlodipine vs. Monotherapies was evaluated on Blood pressure reduction and control. A narrative review of four studies found that a fixed-dose combination of bisoprolol and amlodipine effectively reduced blood pressure and improved adherence compared to monotherapies.