Higher proximal wall shear stress predicted myocardial infarction (HR 1.234; p=0.002) in patients with stable CAD and hemodynamically significant lesions, adding prognostic value over FFR.
Case-Control (n=58)
Hazard Ratio: 1.234
valor p: p=0.002
BACKGROUND Coronary lesions with low fractional flow reserve (FFR) that are treated medically are associated with higher revascularization rates. High wall shear stress (WSS) has been linked with increased plaque vulnerability. OBJECTIVES This study investigated the prognostic value of WSS measured in the proximal segments of lesions (WSSprox) to predict myocardial infarction (MI) in patients with stable coronary artery disease (CAD) and hemodynamically significant lesions. The authors hypothesized that in patients with low FFR and stable CAD, higher WSSprox would predict MI. METHODS Among 441 patients in the FAME II (Fractional Flow Reserve Versus Angiography for Multivessel Evaluation II) trial with FFR ≤0.80 who were randomized to medical therapy alone, 34 (8%) had subsequent MI within 3 years. Patients with vessel-related MI and adequate angiograms for 3-dimensional reconstruction (n = 29) were propensity matched to a control group with no MI (n = 29) by using demographic and clinical variables. Coronary lesions were divided into proximal, middle, and distal, along with 5-mm upstream and downstream segments. WSS was calculated for each segment. RESULTS Median age was 62 years, and 46 (79%) were male. In the marginal Cox model, whereas lower FFR showed a trend (hazard ratio: 0.084; p = 0.064), higher WSSprox (hazard ratio: 1.234; p = 0.002, C-index = 0.65) predicted MI. Adding WSSprox to FFR resulted in a significant increase in global chi-square for predicting MI (p = 0.045), a net reclassification improvement of 0.69 (p = 0.005), and an integrated discrimination index of 0.11 (p = 0.010). CONCLUSIONS In patients with stable CAD and hemodynamically significant lesions, higher WSS in the proximal segments of atherosclerotic lesions is predictive of MI and has incremental prognostic value over FFR.
“We've made a lot of progress on defining and identifying 'vulnerable plaque'. The techniques we're using are now fast enough that they could help guide clinical decision-making.”
Kumar et al. (Mon,) conducted a case-control in Stable coronary artery disease (n=58). High proximal wall shear stress (WSSprox) vs. Lower proximal wall shear stress was evaluated on Myocardial infarction (HR 1.234, p=0.002). Higher proximal wall shear stress predicted myocardial infarction (HR 1.234; p=0.002) in patients with stable CAD and hemodynamically significant lesions, adding prognostic value over FFR.