Severely decreased LVEF (<20%) was strongly associated with the presence of left ventricular thrombus in patients with chemotherapy-induced cardiomyopathy (OR 36.30; 95% CI 7.35-179.25; P<0.0001).
Cohort (n=121)
No
What echocardiographic measures are associated with the presence of left ventricular thrombus in patients with chemotherapy-related severe cardiac dysfunction?
In patients with chemotherapy-induced cardiomyopathy and LVEF ≤ 30%, LV thrombus is present in 7.4% and is strongly associated with LVEF < 20% and a restrictive filling pattern.
Odds Ratio: 36.3 (95% CI 7.35–179.25)
valor p: p=<.0001
BACKGROUND: Previous studies have not evaluated the prevalence and specific risk factors for the development of left ventricular (LV) thrombus in patients with severely reduced left ventricular dysfunction due to chemotherapy-related cardiomyopathy. We sought to evaluate the prevalence and potential markers of LV thrombus in this patient population. METHODS: From January 2009 to December 2013, patients with chemotherapy-related severe LV dysfunction (LV ejection fraction LVEF ≤ 30%) identified from MD Anderson Cancer Center database were reviewed. Patient characteristics and echocardiographic parameters were analyzed to determine potential risk factors for LV thrombus. RESULTS: A total of 121 patients met inclusion criteria (age 54.8 ± 15.2 years; female 63.6%; LVEF 26.3 ± 4%). LV thrombus was present in 9 patients (7.4%). Patients with LV thrombus have significantly lower LVEF compared to those without (18.7 ± 3.8% vs 26.9 ± 3.4%, P < .0001). Prevalence of LV thrombus increased as LVEF decreased and was the highest in patients with LVEF < 20%. By univariate analysis, decreased LVEF, particularly LVEF < 20% (OR 36.30, 95% CI 7.35-179.25, P < .0001) and restrictive LV filling pattern (OR 18.13, 95% CI 4.17-78.89, P = .0001) were associated with presence of LV thrombus. CONCLUSION: In patients with severely reduced LV systolic function due to chemotherapy-induced cardiomyopathy, LV thrombus was found in 7.4% of subjects. Severely decreased LVEF (<20%) and restrictive LV filling pattern were associated with the presence of LV thrombus.
Kitkungvan et al. (Fri,) conducted a cohort in Chemotherapy-related severe left ventricular dysfunction (n=121). Severely decreased LVEF (<20%) vs. LVEF ≥ 20% was evaluated on Presence of left ventricular thrombus (OR 36.30, 95% CI 7.35-179.25, p=<.0001). Severely decreased LVEF (<20%) was strongly associated with the presence of left ventricular thrombus in patients with chemotherapy-induced cardiomyopathy (OR 36.30; 95% CI 7.35-179.25; P<0.0001).