The derived amino acid sequences of human rhinovirus types 89 and 2 showed extensive similarity, whereas similarity between types 89 and 14 was considerably less.
Human rhinoviruses may be more closely related than previously thought, based on extensive sequence similarity between types 89 and 2.
The complete nucleotide sequence of the genome of human rhinovirus type 89 was determined from the cDNA that had been cloned into Escherichia coli. The genome is 7152 nucleotides long and contains a single large open reading frame of 2164 codons. Translation commences at position 619 and ends 42 nucleotides before the poly(A) tract. The positions of three proteolytic cleavage sites in the polyprotein were determined by N-terminal amino acid sequencing of the capsid proteins; the remainder were predicted from comparisons with other picornaviruses. Extensive similarity between the derived amino acid sequences of human rhinovirus types 89 and 2 was found, whereas the similarity between human rhinovirus types 89 and 14 was considerably less. It is apparent that human rhinoviruses may be more closely related than has been previously thought.
Duechler et al. (1987) studied Human rhinovirus. Nucleotide sequencing of human rhinovirus type 89 vs. Human rhinovirus types 2 and 14 was evaluated on Nucleotide and amino acid sequence similarity. The derived amino acid sequences of human rhinovirus types 89 and 2 showed extensive similarity, whereas similarity between types 89 and 14 was considerably less.
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