A 1-unit increase in childhood risky family score was associated with a 1.0% higher calculated 10-year CHD risk in both women (95% CI 0.4-1.7%) and men (95% CI 0.2-1.8%).
Cohort (n=3,554)
Does a risky childhood family psychosocial environment increase calculated 10-year CHD risk in young adults?
A risky childhood family psychosocial environment is associated with a higher calculated 10-year CHD risk in adulthood, potentially mediated by socioeconomic and psychosocial factors.
Estimación del efecto: 1.0% higher CHD risk per 1-unit increase (95% CI 0.4%-1.7% (women); 0.2%-1.8% (men))
OBJECTIVE: Little is known about whether the childhood family psychosocial environment affects coronary heart disease (CHD). Study objectives were to evaluate associations of childhood family psychosocial environment (termed "risky families"; characterized by cold, unaffectionate interactions, conflict, aggression, neglect, and/or low nurturance) with calculated risk for CHD. METHODS: Study participants included 3554 participants of the Coronary Artery Risk Development in Young Adults Study, aged 33 to 45 years. Childhood family psychosocial environment was measured using a risky family questionnaire via self-report. Ten-year CHD risk was calculated using the validated Framingham risk algorithm. RESULTS: In a multivariable-adjusted regression analysis adjusted for age, race/ethnicity, and childhood socioeconomic position, a 1-unit (range, 0-21) increase in risky family score was associated with 1.0% (95% confidence interval = 0.4%-1.7%) and 1.0% (95% confidence interval = 0.2%-1.8%) higher CHD risk in women and men, respectively. Multiple mediation analyses suggested significant indirect effects of education, income, depressive symptomatology, and anger-out expression in women and education in men, indicating that these may be mediating mechanisms between childhood psychosocial environment and CHD risk. Of the modifiable Framingham algorithm components, smoking (in women and men) and high-density lipoprotein (in women) were the factors most strongly associated with risky family score. CONCLUSIONS: Childhood family psychosocial environment was positively associated with the calculated 10-year CHD risk. Mechanisms may include the potential negative impact of childhood family psychosocial environment on later-life socioeconomic position (e.g., education in men and women) and/or psychosocial functioning (e.g., depression and anger-out expression in women), which may in turn lead to higher CHD risk, particularly through smoking (in men and women) and low level of high-density lipoprotein cholesterol (in women).
Loucks et al. (Wed,) conducted a cohort in Coronary heart disease risk (n=3,554). Childhood family psychosocial environment (risky family score) vs. Lower risky family score was evaluated on Calculated 10-year CHD risk (1.0% higher CHD risk per 1-unit increase, 95% CI 0.4%-1.7% (women); 0.2%-1.8% (men)). A 1-unit increase in childhood risky family score was associated with a 1.0% higher calculated 10-year CHD risk in both women (95% CI 0.4-1.7%) and men (95% CI 0.2-1.8%).