Rational Design of Meso -Diaminopimelate Dehydrogenase with Enhanced Reductive Amination Activity for Efficient Production of d - p -Hydroxyphenylglycine

d - p -hydroxyphenylglycine ( d -HPG) is an important intermediate in the synthesis of antimicrobial compounds. d -HPG is mainly produced via chemical and enzymatic approaches, and enzymatic asymmetric amination employing diaminopimelate dehydrogenase (DAPDH) is considered an attractive method.