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October 1, 1994Open Access

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The role of interleukin 12 in the immune response, disease and therapy

Giorgio TrinchieriThe Wistar Institute PSPhillip ScottThe Wistar Institute

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Resumen

The heterodimeric cytokine interleukin 12 (IL-12) stimulates cytotoxicity and cytokine production by T cells and natural killer (NK) cells, and initiates development of CD4+ T helper 1 (Th1) cells. A recent meeting defined how IL-12 contributes to immune responses in disease, as well as how IL-12 can be used to circumvent disease.

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Cite This Study

Trinchieri et al. (Sat,) studied this question.

synapsesocial.com/papers/6a63af2384b804377828daf6 https://doi.org/https://doi.org/10.1016/0167-5699(94)90189-9

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Interleukin-12 and its role in the generation of TH1 cells1993 · 852 citations
2THE TREATMENT OF MALIGNAT TUMORS BY REPEATED INOCULATIONS OF ERYSIPELAS1893 · 981 citations
3Cloning and expression of murine IL-121992 · 470 citations
4Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells1991 · 856 citations
5Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes.1989 · 1,976 citations

El papel de la interleucina 12 en la respuesta inmune, enfermedad y terapia | Synapse