Organocatalytic Enantioselective Morita–Baylis–Hillman Reaction of Maleimides with Isatins

Abstract An enantioselective Morita–Baylis–Hillman reaction of maleimides with isatin derivatives has been developed. β‐Isocupreidine catalyzes the formation of enantiomerically enriched 3‐substituted 3‐hydroxyoxindole derivatives in up to 96 % yield and enantioselectivity of over 99 % ee can be achieved under mild reaction conditions.