In heart failure, the muscle metaboreflex shifts from increasing cardiac output to causing peripheral vasoconstriction, likely due to depressed arterial baroreflex buffering.
How does heart failure alter the cardiovascular responses mediated by the muscle metaboreflex during exercise in animal models?
This review highlights that in heart failure, the muscle metaboreflex response during exercise shifts from increasing cardiac output to causing peripheral vasoconstriction, explaining the enhanced sympatho-excitation seen in this condition.
This brief review summarizes recent studies describing the potential role of the muscle metaboreflex in mediating the altered cardiovascular responses to dynamic exercise in heart failure and the interaction between the muscle metaboreflex and the arterial baroreflex in these responses. In normal dogs, activation of the muscle metaboreflex (via partial reductions in hindlimb blood flow) during submaximal exercise, elicits a powerful pressor response. This increase in arterial pressure is mediated by an increase in cardiac output with little, if any, peripheral vasoconstriction. The metaboreflex pressor response is buffered by the arterial baroreflex via baroreflex-mediated inhibition of metaboreflex-induced peripheral vasoconstriction. In contrast, after induction of heart failure, the mechanisms involved in the muscle metaboreflex are shifted to vasoconstriction with little, if any, increase in cardiac output. The loss of the cardiac output response of the metaboreflex in heart failure probably stems from inability to improve ventricular function. The shift towards vasoconstriction in this setting may be due to depressed ability of the arterial baroreflex to buffer metaboreflex-induced peripheral vasoconstriction. The relative underperfusion of active skeletal muscle in heart failure may tonically activate the metaboreflex and this probably contributes to the enhanced sympatho-excitation seen during exercise in heart failure.
Donal S. O’Leary (Fri,) conducted a review in Heart failure. Muscle metaboreflex activation during exercise vs. Normal state was evaluated on Cardiovascular responses to dynamic exercise. In heart failure, the muscle metaboreflex shifts from increasing cardiac output to causing peripheral vasoconstriction, likely due to depressed arterial baroreflex buffering.