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The potential of polygenic scores to improve cost and efficiency of clinical trials | Synapse

May 25, 2022Open Access

The potential of polygenic scores to improve cost and efficiency of clinical trials

AFAkl C. FahedInterventional / Structural Cardiology APAnthony PhilippakisGeneral Cardiology AKAmit V. KheraPreventive Cardiology

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Resumen

Polygenic scores can identify individuals with high disease risk based on inborn DNA variation. We explore their potential to enrich clinical trials by identifying individuals based on higher risk of disease (‘prognostic enrichment’), or increased probability of benefit (‘predictive enrichment’).

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Fahed et al. (Wed,) studied this question.

synapsesocial.com/papers/6a6db0afe5469ee92bdfd263 https://doi.org/https://doi.org/10.1038/s41467-022-30675-z

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