Increased insulin and leptin sensitivity in mice lacking acyl CoA:diacylglycerol acyltransferase 1

MethodsMice.Dgat1 -/-mice (95% C57BL/6 and 5% 129/SvJae background) were generated previously (4).Wild-type (Dgat1 +/+ ), ob/+, and A Y /a mice (all in C57BL/6 background) were from the The Jackson Laboratory (Bar Harbor, Maine, USA).A Y /a mice are obese and insulin resistant, reflecting the antagonism of melanocyte-