January 5, 2012New England Journal of Medicine462 citations

TET2andDNMT3AMutations in Human T-Cell Lymphoma

LCLucile CouronnéHôpital Necker-Enfants Malades CBChristian BastardCentre de Droit Maritime et Océanique OBOlivier BernardUniversité Paris-Sud

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Resumen

A substantial fraction of T-cell lymphomas carry mutations in two genes — TET2 and DNMT3A — that are involved in DNA methylation. The co-occurrence of these mutations suggests that inhibitors of DN...

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Couronné et al. (Thu,) studied this question.

synapsesocial.com/papers/6a75dffe74b63c188eb20062 https://doi.org/https://doi.org/10.1056/nejmc1111708

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4Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET22010 · 1,296 citations
5TET2 Inactivation Results in Pleiotropic Hematopoietic Abnormalities in Mouse and Is a Recurrent Event during Human Lymphomagenesis2011 · 906 citations

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