Does a damaged baroreceptor reflex increase the development of arterial hypertension in Wistar male rats undergoing renal artery clipping?
The baroreceptor reflex counteracts the development of vasorenal hypertension and plays a role in long-term blood pressure regulation in a rat model.
Less than 50 % Wistar male rats with intact baroreceptor reflex developed arterial hypertension 8 weeks after renal artery clipping in the model «two kidneys - one clip». Blood pressure level negatively correlated with initial magnitude of the baroreceptor reflex. At the same time all rats (100 %) with the damaged baroreceptor reflex developed hypertension after renal artery clipping. Thus, we conclude that baroreceptor reflex counteracts the development of vasorenal hypertension and it can take part in blood pressure long-term regulation.
Цырлин et al. (2009) studied this question.