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February 15, 2024Circulation87 citationsOpen Access

Clonal Hematopoiesis of Indeterminate Potential With Loss of Tet2 Enhances Risk for Atrial Fibrillation Through Nlrp3 Inflammasome Activation

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ALAmy E. LinABAneesh BapatLXLing Xiao

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Abstract

Clonal hematopoiesis of indeterminate potential (CHIP), a common age-associated phenomenon, associates with increased risk of both hematological malignancy and cardiovascular disease. Although CHIP is known to increase the risk of myocardial infarction and heart failure, the influence of CHIP in cardiac arrhythmias, such as atrial fibrillation (AF), is less explored.

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Lin et al. (2024) studied this question.

synapsesocial.com/papers/68e78f53b6db643587700e7bhttps://doi.org/10.1161/circulationaha.123.065597
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