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January 6, 2026Journal of Biochemical and Molecular Toxicology

Heme Oxygenase‐1 Regulates the JAK/STAT Pathway to Inhibit Ferroptosis in Metabolic Dysfunction‐Associated Steatotic Liver Disease

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Authors

LYLi YaoXQXinze QiuJZJun Zou

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Overview

Study reveals heme oxygenase-1 reduces ferroptosis and improves liver function in MASLD, indicating possible therapeutic targets.

Key Points

  • Investigate the role of heme oxygenase-1 in regulating ferroptosis in metabolic dysfunction-associated steatotic liver disease.
  • Utilized bioinformatics to identify ferroptosis-related genes
  • Conducted immunohistochemistry to validate HMOX1 expression
  • Administered hemin to MCD-diet fed mice for 8 weeks and analyzed outcomes
  • Performed cell transfection in HL7702 cells with HMOX1 and assessed lipid peroxidation and viability
  • Conducted Western blotting to explore molecular mechanisms
  • HMOX1 was identified as a hub gene related to ferroptosis in MASLD datasets
  • Mice displayed elevated ALT, AST, TG, LDL, and ROS with reduced HMOX1
  • Hemin treatment improved liver condition and inhibited ferroptosis
  • JAK/STAT pathway activation was noted, with HMOX1 upregulating and reversing lipid peroxidation

Cite This Study

Yao et al. (2026) studied this question.

synapsesocial.com/papers/695d85543483e917927a4a7fhttps://doi.org/10.1002/jbt.70661
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