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November 9, 2004New England Journal of Medicine1,784 citations

Combination of Isosorbide Dinitrate and Hydralazine in Blacks with Heart Failure

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ATAnne L. TaylorSZSusan ZiescheCYClyde W. Yancy

Key Result

The addition of isosorbide dinitrate plus hydralazine to standard therapy significantly increases survival in black patients with advanced heart failure.

Structured PICO

Does a fixed dose of isosorbide dinitrate plus hydralazine added to standard therapy increase survival in black patients with advanced heart failure?

P
Population
Black patients with advanced heart failure
I
Intervention
Fixed dose of isosorbide dinitrate plus hydralazine added to standard therapy including neurohormonal blockers
C
Comparator
Standard therapy for heart failure including neurohormonal blockers
O
Outcome
Survivalhard clinical

The combination of isosorbide dinitrate and hydralazine added to standard therapy increases survival in black patients with advanced heart failure.

Abstract

The addition of a fixed dose of isosorbide dinitrate plus hydralazine to standard therapy for heart failure including neurohormonal blockers is efficacious and increases survival among black patients with advanced heart failure.

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Cite This Study

Taylor et al. (2004) studied this question. The addition of isosorbide dinitrate plus hydralazine to standard therapy significantly increases survival in black patients with advanced heart failure.

synapsesocial.com/papers/697817f9f226c9e734a25b70https://doi.org/10.1056/nejmoa042934
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