Does the type of atrial fibrillation (paroxysmal vs. persistent/permanent) affect the risk of heart failure hospitalization and stroke in patients with HFrEF?
In patients with HFrEF, paroxysmal AF is associated with a higher risk of HF hospitalization and stroke compared to persistent or permanent AF, emphasizing the importance of anticoagulant therapy.
Among HF patients with a history of AF, those with paroxysmal AF were at greater risk of HF hospitalization and stroke than were patients with persistent or permanent AF, underlining the importance of anticoagulant therapy. New onset AF was associated with increased risk of all outcomes. (Prospective comparison of ARNI with ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure PARADIGM-HF; NCT01035255) (Aliskiren Trial to Minimize Outcomes in Patients with Heart Failure ATMOSPHERE; NCT00853658).
Mogensen et al. (2017) studied this question.