Objective: To evaluate the impact of cognitive behavioural therapy combined with tadalafil on the recovery of urinary and sexual function in patients with functional erectile dysfunction (ED) and moderate to severe lower urinary tract symptoms (LUTS). Methods: This was a retrospective cohort study that involving a total of 236 patients. Patients were divided into two groups: the Tadalafil Group (n = 121) was given an oral dose of 5 mg of tadalafil daily for 12 weeks; the Combination Group (n = 115) received the same tadalafil treatment in addition to an additional 12-week course of cognitive behavioural therapy. Biochemical markers, urodynamic parameters, urinary function, sexual function, psychological state, and quality of life were compared between the two groups before and after treatment. Results: Following treatment, the Combination Group demonstrated significantly greater improvements in interleukin-6 levels, cortisol levels, urodynamic parameters, sexual function markers, anxiety and depression scores, and quality of life compared with the Tadalafil Group (all p Conclusions: For patients with functional ED complicated by moderate to severe LUTS, the combination of cognitive behavioural therapy and tadalafil is a promising integrated treatment strategy that can more effectively improve their urinary function, sexual function, psychological state, and quality of life.
A 2026 study studied this question.