Prospective case-control study evaluates claudin-5 and inflammation in wet and dry AMD, suggesting limited utility as biomarkers.
Key Points
This research aimed to assess circulating claudin-5 levels and systemic inflammatory indices in patients with wet and dry age-related macular degeneration (AMD).
Prospective case-control study including 90 participants: 30 wet AMD, 30 dry AMD, and 30 healthy controls.
Patients underwent detailed eye examinations, and serum claudin-5 levels were analyzed using ELISA.
Systemic inflammatory indices were calculated from complete blood counts and analyzed statistically.
Median serum claudin-5 levels were 2.42 in controls, 3.28 in wet AMD, and 3.10 in dry AMD with no significant differences (p=0.280).
PLR was higher in dry AMD compared to wet AMD (p=0.019), but not significant after age adjustment (adjusted p=0.098).
No significant correlations were found between claudin-5 and age, visual function, or systemic inflammatory indices.