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August 1, 2004Current Pharmaceutical DesignOpen Access

New generation antidepressants and antipsychotics inhibit cardiac and vascular Na+, Ca2+ and K+ channels, leading to clinically important cardiovascular side effects such as arrhythmias, prolonged QTc interval, and orthostatic hypotension.

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Why the study?

Do new generation antidepressants and antipsychotics cause cardiovascular side effects such as arrhythmias and QTc prolongation?

Population

Patients taking new antidepressants and antipsychotics, including those without underlying cardiovascular…

Design

Review

Authors

PPPál PacherVKValéria Kecskeméti

Discussion

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Overview

May warrant ECG monitoring in at-risk patients; leaves open the incidence and causality of channel-mediated effects.

Structured PICO

Do new generation antidepressants and antipsychotics cause cardiovascular side effects such as arrhythmias and QTc prolongation?

P
Population
Patients taking new antidepressants (SSRIs) and antipsychotics, including those without underlying cardiovascular disorders
I
Intervention
New generation antidepressants (SSRIs: fluoxetine, fluvoxamine, paroxetine, sertraline, citalopram, venlafaxin) and antipsychotics (clozapine, olanzapine, risperidone, sertindole, aripiprazole, ziprasidone, quetiapine)
O
Outcome
Cardiovascular side effects including arrhythmias, prolonged QTc interval, and orthostatic hypotensionsafety

New generation antidepressants and antipsychotics have clinically important cardiovascular side effects, including arrhythmias and QTc prolongation, warranting ECG monitoring especially in patients with cardiovascular disorders.

Cite This Study

Pacher et al. (2004) studied this question.

synapsesocial.com/papers/6a01c7371adb974501caf7c7https://doi.org/10.2174/1381612043383872
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