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December 15, 2016Diabetes818 citationsOpen Access

Differentiation of Diabetes by Pathophysiology, Natural History, and Prognosis

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JSJay S. SkylerGBGeorge L. BakrisEBEzio Bonifacio

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Abstract

The American Diabetes Association, JDRF, the European Association for the Study of Diabetes, and the American Association of Clinical Endocrinologists convened a research symposium, "The Differentiation of Diabetes by Pathophysiology, Natural History and Prognosis" on 10-12 October 2015. International experts in genetics, immunology, metabolism, endocrinology, and systems biology discussed genetic and environmental determinants of type 1 and type 2 diabetes risk and progression, as well as complications. The participants debated how to determine appropriate therapeutic approaches based on disease pathophysiology and stage and defined remaining research gaps hindering a personalized medical approach for diabetes to drive the field to address these gaps. The authors recommend a structure for data stratification to define the phenotypes and genotypes of subtypes of diabetes that will facilitate individualized treatment.

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Skyler et al. (2016) studied this question.

synapsesocial.com/papers/6a03b2f51506208190f016f0https://doi.org/10.2337/db16-0806
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