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July 3, 2012Hypertension

Relationship Between Short-Term Blood Pressure Variability and Large-Artery Stiffness in Human Hypertension

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Why the study?

Is short-term blood pressure variability associated with large-artery stiffness in patients with hypertension?

Population

3,000 hypertensive patients, comprising a learning population of 911 untreated, nondiabetic patients with…

Design

Cross-sectional

Authors

GSGiuseppe SchillaciGBGrzegorz BiloGPGiacomo Pucci

Discussion

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Overview

Hypothesis-generating for SBP variability as aortic stiffness marker in hypertension; prospective studies needed before clinical adoption.

Structured PICO

Is short-term blood pressure variability associated with large-artery stiffness in patients with hypertension?

P
Population
3,000 hypertensive patients, comprising a learning population of 911 untreated, nondiabetic patients with uncomplicated hypertension, and a test population of 2,089 mostly treated hypertensive patients (83% treated, 25% diabetics).
I
Intervention
Assessment of short-term systolic blood pressure (SBP) variability using 24-hour ambulatory BP monitoring (calculated as SD of 24-hour, daytime, or nighttime SBP; weighted SD of 24-hour SBP; and average real variability [ARV]).
O
Outcome
Carotid-femoral pulse wave velocity (cfPWV) as a measure of large-artery stiffness.surrogate

Short-term variability of 24-hour systolic blood pressure is independently associated with aortic stiffness in hypertensive patients, particularly when measured using average real variability or weighted 24-hour standard deviation.

Cite This Study

Schillaci et al. (2012) studied this question.

synapsesocial.com/papers/6a03eca15ea3557592893ad3https://doi.org/10.1161/hypertensionaha.112.197491
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