Why the study?
Psychological stress can provoke and aggravate myocardial ischemia, but methods to establish and evaluate a rat model of myocardial ischemia with psychological stress had not been investigated.
Population
Forty male Wistar rats
Comparison
Sham vs MI vs psychological stress vs MI with psychological stress
Design
Randomized preclinical animal study
Follow-up
14 days
Key result
A rat model of myocardial ischemia with psychological stress was successfully established, showing aggravated behavioral disorder, microcirculation dysfunction, and myocardial damage compared to MI alone.
Authors
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This rat model enables mechanistic studies of stress-MI interaction; leaves open translation to human disease.
A rat model of myocardial ischemia with psychological stress was successfully established, demonstrating that psychological stress aggravates myocardial damage and microcirculation dysfunction.
Wang et al. (2020) studied Myocardial ischemia with psychological stress (n=40). Psychological stress and myocardial infarction vs. Sham, myocardial infarct alone, or psychological stress alone was evaluated on Behavioral parameters, microcirculation, hemodynamics, and myocardial damage markers (cTnT, Hcy, LDH, infarct size). A rat model of myocardial ischemia with psychological stress was successfully established, showing aggravated behavioral disorder, microcirculation dysfunction, and myocardial damage compared to MI alone.