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July 14, 2010International Journal of Epidemiology516 citationsOpen Access

Non-vigorous physical activity and all-cause mortality: systematic review and meta-analysis of cohort studies

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JWJames WoodcockUniversity of CambridgeOFOscar H. FrancoBoston UniversityNONicola OrsiniHeart Failure & Transplant

Key Result

Non-vigorous physical activity of 2.5 hours/week and 7 hours/week compared with no activity reduced all-cause mortality risk by 19% (95% CI 15-24) and 24% (95% CI 19-29), respectively.

Study Design

Type

Meta-Analysis (n=977,925)

Structured PICO

Does non-vigorous physical activity reduce all-cause mortality in adults?

P
Population
977,925 adults (334,738 men and 643,187 women) pooled from 22 cohort studies with sample sizes >10,000
I
Intervention
Different levels of light or moderate (non-vigorous) physical activity (e.g., 2.5 h/week or 7 h/week)
C
Comparator
No activity
O
Outcome
All-cause mortalityhard clinical

Non-vigorous physical activity, even at low levels such as 2.5 hours per week, is associated with a significant reduction in all-cause mortality compared to no activity.

Main Result

Effect estimate: 19% risk reduction (95% CI 15-24)

Limitations

  • Considerable variation between the studies in their categorization of physical activity and adjustment for potential confounders

Abstract

BACKGROUND: Although previous studies have found physical activity to be associated with lower mortality, the dose-response relationship remains unclear. In this systematic review and meta-analysis we quantify the dose-response relationship of non-vigorous physical activity and all-cause mortality. METHODS: We aimed to include all cohort studies in adult populations with a sample size of more than 10 000 participants that estimated the effect of different levels of light or moderate physical activity on all-cause mortality. We searched Medline, Embase, Cochrane (DARE), Web of Science and Global Health (June 2009). We used dose-response meta-regression models to estimate the relation between non-vigorous physical activity and mortality. RESULTS: We identified 22 studies that met our inclusion criteria, containing 977 925 (334 738 men and 643 187 women) people. There was considerable variation between the studies in their categorization of physical activity and adjustment for potential confounders. We found that 2.5 h/week (equivalent to 30 min daily of moderate intensity activity on 5 days a week) compared with no activity was associated with a reduction in mortality risk of 19% 95% confidence interval (CI) 15-24, while 7 h/week of moderate activity compared with no activity reduced the mortality risk by 24% (95% CI 19-29). We found a smaller effect in studies that looked at walking alone. CONCLUSION: Being physically active reduces the risk of all-cause mortality. The largest benefit was found from moving from no activity to low levels of activity, but even at high levels of activity benefits accrue from additional activity.

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Cite This Study

Woodcock et al. (2010) reported a meta-analysis. Non-vigorous physical activity vs. No activity was evaluated on All-cause mortality (19% risk reduction, 95% CI 15-24). Non-vigorous physical activity of 2.5 hours/week and 7 hours/week compared with no activity reduced all-cause mortality risk by 19% (95% CI 15-24) and 24% (95% CI 19-29), respectively.

synapsesocial.com/papers/6a11f3b37a39277672ad0989https://doi.org/10.1093/ije/dyq104
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