Why the study?
Does prorenin receptor deletion in principal cells versus intercalated cells alter renal sodium and water excretion in mice?
Population
Mice with principal cell or intercalated cell prorenin receptor deletion
Comparison
Deletion of prorenin receptor in principal cells… vs Control mice
Design
Preclinical
Key result
Principal cell prorenin receptor deletion in mice reduced ENaC-α abundance, increased urinary Na+ losses, and increased urine volume compared with controls, whereas intercalated cell deletion did not.
Authors
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Prorenin receptor in principal cells may influence sodium balance; extends mechanistic insights in mice but leaves human translation open.
Does prorenin receptor deletion in principal cells versus intercalated cells alter renal sodium and water excretion in mice?
The prorenin receptor in principal cells, but not intercalated cells, modulates ENaC activity, urinary sodium excretion, and water transport in the collecting duct.
Ramkumar et al. (2018) studied Renal sodium and water handling. Principal cell (PC) or intercalated cell (IC) prorenin receptor (PRR) deletion vs. Control mice was evaluated on Renal Na+ and water handling (ENaC activity, urinary Na+ excretion, and water transport). Principal cell prorenin receptor deletion in mice reduced ENaC-α abundance, increased urinary Na+ losses, and increased urine volume compared with controls, whereas intercalated cell deletion did not.