Heart rate variability, baroreceptor reflex sensitivity, and baroreceptor effectiveness index are reduced in end-stage renal disease and can serve as prognostic indicators for cardiovascular mortality.
Can heart rate variability, baroreceptor sensitivity, and baroreceptor reflex effectiveness index predict cardiovascular mortality in patients with end-stage renal disease?
Heart rate variability, baroreceptor sensitivity, and baroreceptor reflex effectiveness index may serve as useful prognostic markers for cardiovascular mortality in patients with end-stage renal disease.
Although the annual mortality rate for end-stage renal disease (ESRD) is decreasing, likely due to an increase in kidney transplantation rate, the survival probability for ESRD patients from day one of dialysis has not changed, and is still poor with a 5-year survival rate of approximately 34%. This is contributed to by a high prevalence of cardiovascular disease, which is the leading cause of death in ESRD patients. In order to improve survival outcomes, patients at high risk of cardiovascular related mortality need to be identified. Heart rate variability (HRV), baroreceptor sensitivity, and baroreceptor reflex effectiveness index can be used to assess heart rate control and may predict cardiovascular mortality. This paper will discuss how HRV, baroreceptor sensitivity, and baroreceptor reflex effectiveness index are altered in renal disease and the utility of these indices as markers of cardiac risk in this patient population.
Cara M. Hildreth (2012) conducted a review in Chronic Kidney Disease and End-Stage Renal Disease. Heart rate variability, baroreceptor reflex sensitivity, and baroreceptor effectiveness index are reduced in end-stage renal disease and can serve as prognostic indicators for cardiovascular mortality.