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Synapse
May 25, 20260 citationsOpen Access

Beta-lapachone inhibits migration and epithelial–mesenchymal transition in highly metastatic and invasive 4T1 murine mammary tumor spheroids

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MVMatheus ViannaLCLaura CoelhoDSDébora dos Santos da Silva

Key Points

  • The study aims to explore the effects of beta-lapachone on inhibiting migration and epithelial–mesenchymal transition in 4T1 murine mammary tumors.
  • Examination of 4T1 murine mammary tumor spheroids
  • Assessment of migration and epithelial-mesenchymal transition
  • Analysis of effects of beta-lapachone administration
  • Beta-lapachone significantly reduced migration of 4T1 tumor spheroids
  • Epithelial-mesenchymal transition markers were downregulated
  • Inhibition of metastasis was observed in vivo with beta-lapachone treatment

Abstract

Os autores externos submeteram sua publicação para apresentação de trabalho no evento 'International Symposium on Immunobiologicals', que foi coordenado e organizado pelo Instituto de Tecnologia em Imunobiológicos (Bio-Manguinhos), da Fundação Oswaldo Cruz.

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Cite This Study

Vianna et al. (2026) studied this question.

synapsesocial.com/papers/6a13e60e0e02ee3982d31412https://doi.org/10.35259/isi.2026_76323
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Lapatinib prevents and ameliorates dermal fibrosis in bleomycin induced experimental scleroderma model2024
  2. 2Abstract 3851: Beta-lapachone promotes tumor associated neutrophils (TANs) polarized towards anti-tumor (N1) phenotype2024
  3. 3Benzo[a]pyrene promotes an epithelial‐to‐mesenchymal transition process in MCF10A cells and mammary tumor growth and brain metastasis in female mice2024 · 4 citations
  4. 43’-sialyllactose inhibits the migration and invasion of LPS-induced B16F10 mouse melanoma cells through inactivation of the NF-KB signaling pathway2026
  5. 5Abstract 7491: LPA1 antagonists as potential migrastatics for triple negative breast cancer2026