Why the study?
Does echocardiography accurately estimate right ventricular systolic pressure compared to right heart catheterization in murine models of pulmonary hypertension?
Population
Mice with pulmonary hypertension induced acutely by infusion of a thromboxane analogue or chronically by…
Comparison
Echocardiography to measure pulmonary… vs Simultaneous right ventricle catheterization to…
Design
Preclinical
Key result
Noninvasive echocardiographic measurement of pulmonary acceleration time to ejection time ratio strongly correlated with invasive right ventricular systolic pressure in mice (r2=-0.76, P<0.0001).
Authors
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Supports noninvasive RVSP estimation in murine PH models; extends preclinical validation but leaves open clinical translation.
Does echocardiography accurately estimate right ventricular systolic pressure compared to right heart catheterization in murine models of pulmonary hypertension?
Effect estimate: r2=-0.76
p-value: p=<0.0001
Echocardiography-derived pulmonary acceleration time and ejection time provide a reliable, noninvasive method to estimate right ventricular systolic pressure in murine models of pulmonary hypertension.
Thibault et al. (2010) studied Pulmonary arterial hypertension (murine model). Echocardiography (pulmonary acceleration time and ejection time) vs. Right heart catheterization (invasive RVSP) was evaluated on Correlation of pulmonary acceleration time to ejection time ratio (PAT/ET) with right ventricular systolic pressure (r2=-0.76, p=<0.0001). Noninvasive echocardiographic measurement of pulmonary acceleration time to ejection time ratio strongly correlated with invasive right ventricular systolic pressure in mice (r2=-0.76, P<0.0001).