Pulsed Doppler tissue imaging quantified ischemia-induced regional myocardial dysfunction, with systolic velocity decreases correlating with systolic shortening (r=0.90, P<0.0001).
Does pulsed Doppler tissue imaging accurately quantify regional myocardial dysfunction induced by acute ischemia and reperfusion in a porcine model?
Pulsed Doppler tissue imaging accurately quantifies ischemia-induced regional myocardial dysfunction, correlating strongly with established invasive measurements.
Effect estimate: r=0.90 and r=0.96
p-value: p=<.0001
BACKGROUND: Quantification of regional myocardial function is a major unresolved issue in cardiology. We evaluated the accuracy of pulsed Doppler tissue imaging (DTI), a new echocardiographic technique, to quantify regional myocardial dysfunction induced by acute ischemia and reperfusion. METHODS AND RESULTS: In nine open-chest anesthetized pigs, various degrees of regional wall motion abnormalities were induced by graded reduction of left anterior descending coronary artery (LAD) blood flow. Pulsed Doppler tissue imaging was performed from an epicardial apical four-chamber view with the sample placed within the middle part of the septal wall. Peak septal velocities were calculated during systole, isovolumic relaxation, and early and late diastole. Regional myocardial blood flow and systolic and diastolic dysfunctions were assessed by radioactive microspheres and ultrasonic crystals, respectively. Ischemia resulted in a significant rapid reduction of systolic velocities and an early decrease in the ratio of early to late diastolic velocities. Both changes were detected by pulsed DTI within 5 seconds of coronary artery occlusion. The decrease in systolic velocity significantly correlated with both systolic shortening (r=.90, P<.0001) and regional myocardial blood flow (r=.96, P<.0001) during reduction of LAD blood flow. CONCLUSIONS: These results suggest that DTI may be a promising new tool for the quantification of ischemia-induced regional myocardial dysfunction.
Dérumeaux et al. (1998) studied Myocardial Ischemia and Reperfusion (n=9). Pulsed Doppler tissue imaging (DTI) vs. Radioactive microspheres and ultrasonic crystals was evaluated on Correlation of decrease in systolic velocity with systolic shortening and regional myocardial blood flow (r=0.90 and r=0.96, p=<.0001). Pulsed Doppler tissue imaging quantified ischemia-induced regional myocardial dysfunction, with systolic velocity decreases correlating with systolic shortening (r=0.90, P<0.0001).