Body mass index was progressively associated with an increased risk of incident ischemic heart disease, with a BMI of 24-<25 yielding an HR of 2.01 (95% CI 1.32-3.05) versus a BMI of 18-<19.
Cohort (n=133,740)
Does higher body mass index increase the risk of incident ischemic heart disease in South Korean adults?
In South Korean adults, there is a progressive, linear association between increasing BMI and incident ischemic heart disease, even within ranges considered normal by Western standards.
Effect estimate: HR 2.01 (95% CI 1.32-3.05)
Asian populations have a higher body fat percentage for a given body mass index (BMI) than Caucasians. However, little information is available on the association of BMI with ischemic heart disease (IHD) incidence in Asians at low BMI levels. The authors prospectively evaluated the association of BMI (weight (kg)/height m2) with IHD incidence over 9 years of follow-up (1993-2001) among 133,740 South Korean adults (89,050 men, 44,690 women) who participated in the 1990 and 1992 examinations of the Korea Medical Insurance Corporation Study. Average BMI at baseline was 23.4 (standard deviation, 2.3) in men and 22.3 (standard deviation, 2.3) in women. After multivariate adjustment, there was a 14% (95% confidence interval: 12, 16) increased risk of incident IHD per unit of increase in BMI. This trend was also observed within the range considered normal by Western standards, and a BMI of 24-<25 was associated with an IHD hazard ratio of 2.01 (95% confidence interval: 1.32, 3.05) in comparison with a BMI of 18-<19. The association of BMI with IHD in this cohort of relatively young South Korean men and women was progressive over the range of BMI values, with no threshold of change in risk and no indication of a U-shaped relation at low BMI levels.
Jee et al. (2005) conducted a cohort in Ischemic heart disease (n=133,740). Body Mass Index vs. Lower BMI (18-<19) was evaluated on Incident ischemic heart disease (HR 2.01, 95% CI 1.32-3.05). Body mass index was progressively associated with an increased risk of incident ischemic heart disease, with a BMI of 24-<25 yielding an HR of 2.01 (95% CI 1.32-3.05) versus a BMI of 18-<19.