Angptl4 deficiency in fasted mice resulted in increased lipoprotein lipase activity and triglyceride uptake specifically in adipose tissue, indicating Angptl4 diverts dietary fat away from adipose during fasting.
ANGPTL4 is induced early during fasting to divert fatty acid and triglyceride uptake away from adipose tissue.
p-value: p=<0.05
Angiopoietin-like 4 (ANGPTL4) is a fasting-induced inhibitor of lipoprotein lipase (LPL) and a regulator of plasma triglyceride metabolism. Here, we examined the kinetics of Angptl4 induction and tested the hypothesis that ANGPTL4 functions physiologically to reduce triglyceride delivery to adipose tissue during nutrient deprivation. Gene expression, LPL activity, and triglyceride uptake were examined in fasted and fed wild-type and Angptl4−/− mice. Angptl4 was strongly induced early in fasting, and this induction was suppressed in mice with access to food during the light cycle. Fasted Angptl4−/− mice manifested increased LPL activity and triglyceride uptake in adipose tissue compared to wild-type mice. Angptl4 is induced early in fasting to divert uptake of fatty acids and triglycerides away from adipose tissues.
Cushing et al. (2017) studied Triglyceride metabolism during fasting. Angptl4 deficiency (Angptl4-/- mice) vs. Wild-type mice was evaluated on Triglyceride uptake in adipose tissue during fasting (p=<0.05). Angptl4 deficiency in fasted mice resulted in increased lipoprotein lipase activity and triglyceride uptake specifically in adipose tissue, indicating Angptl4 diverts dietary fat away from adipose during fasting.