Uncontrolled blood pressure in hypertensive patients led to a greater increase in pulse wave velocity over 3.75 years compared to controlled blood pressure (1.46 vs 0.62 m/s; p<0.05).
Cohort (n=333)
No
What are the determinants of carotid-femoral pulse wave velocity progression in hypertensive patients over a 3.7-year follow-up?
Accelerated arterial aging in treated hypertensive subjects is largely driven by age and blood pressure control, highlighting the importance of achieving BP targets to prevent arterial stiffness progression.
Absolute Event Rate: 1.46% vs 0.62%
p-value: p=< .05
OBJECTIVE: The role of risk factors on the progression of arterial stiffness has not yet been extensively evaluated. The aim of the current longitudinal study was to evaluate the determinants of the PWV progression over a 4 years follow-up period in hypertensive subjects. MATERIALS AND METHODS: We enrolled 333 consecutive hypertensive outpatients 18-80 aged, followed by the Hypertension Unit of St. Gerardo Hospital (Monza, Italy). At baseline anamnestic, clinical, BP, laboratory data and cfPWV were assessed. We performed a PWV follow-up examination with a median time amounting to 3.75 ± 0.53 years. RESULTS: At baseline the mean age was 54.5 ± 12.6 years, SBP and DBP were 141.3 ± 18.6 and 86.4 ± 10.4 mmHg and PWV was 8.56 ± 1.92 m/s. Despite an improvement in BP control (from 37 to 60%), at follow-up the population showed a PWV increase (ΔPWV 0.87 ± 3.05 m/s). PWV and ΔPWV gradually increased in age decades. In patients with uncontrolled BP values at follow-up ΔPWV showed a greater increase as compared to patients with controlled BP (1.46 ± 3.67 vs 0.62 ± 2.61 m/s, p < .05). The independent predictors of ΔPWV were age, baseline PWV, baseline SBP/MBP and ΔSBP/MBP. CONCLUSIONS: the accelerated arterial aging in treated hypertensive subjects is in large measure explained by age and BP values. PWV changes over time would probably give important information that need further future research studies.
Meani et al. (2017) conducted a cohort in Hypertension (n=333). Uncontrolled blood pressure vs. Controlled blood pressure was evaluated on PWV progression (ΔPWV) (p=< .05). Uncontrolled blood pressure in hypertensive patients led to a greater increase in pulse wave velocity over 3.75 years compared to controlled blood pressure (1.46 vs 0.62 m/s; p<0.05).