Why the study?
What are the determinants of warfarin requirements in Chinese patients with deep vein thrombosis and/or pulmonary thromboembolism?
Population
33 Chinese patients presenting with deep vein thrombosis and/or pulmonary thromboembolism
Design
Cohort
Authors
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Supports lower age-guided warfarin dosing in Chinese patients; extends Caucasian observations but remains hypothesis-generating.
What are the determinants of warfarin requirements in Chinese patients with deep vein thrombosis and/or pulmonary thromboembolism?
Chinese patients require a lower mean daily maintenance dosage of warfarin (3 mg) compared to historical Caucasian norms, with age being a significant determinant of dosing requirements.
Chan et al. (1992) studied this question.