PulseExploreJournal ClubResearchersJournals
Instagram
HomeJournal ClubExplore
Synapse
⌘+K
Synapse
January 1, 2015Journal of OncologyOpen Access

Exercise Prevention of Cardiovascular Disease in Breast Cancer Survivors

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does exercise prevent cardiovascular toxicity and modify cardiovascular risk factors in breast cancer survivors?

Population

Breast cancer survivors at elevated risk for cardiovascular disease due to cardiotoxic side effects of…

Design

Review

Key result

Exercise appears to protect against chemotherapy-associated cardiovascular toxicity in breast cancer survivors by improving antioxidant capacity and reducing oxidative stress.

Authors

AKAmy A. KirkhamMDMargot K. Davis

Discussion

Loading...

Member takes

Overview

May support exercise for cardiotoxicity mitigation in breast cancer survivors; leaves open optimal dosing and confirmatory RCTs.

Key Points

  • This work aims to explore how exercise can prevent cardiovascular issues related to breast cancer treatments.
  • Review of existing evidence on exercise's impact on cardiovascular toxicity from chemotherapy.
  • Focus on antioxidant capacity in heart and blood vessels as a mechanism.
  • Suggests clinical measures to assess cardiovascular function.
  • Exercise may enhance antioxidant capacity, reducing oxidative stress in the heart and vasculature.
  • Identifies the need for further research on exercise's effectiveness as a treatment for cardiovascular morbidity.
  • Recommends cardiac strain, endothelial function, and biomarkers as key measures in future studies.

Structured PICO

Does exercise prevent cardiovascular toxicity and modify cardiovascular risk factors in breast cancer survivors?

P
Population
Breast cancer survivors at elevated risk for cardiovascular disease due to cardiotoxic side effects of treatment
I
Intervention
Exercise
O
Outcome
Prevention of cardiovascular toxicity associated with chemotherapy and modification of cardiovascular risk factors

Exercise may protect against chemotherapy-induced cardiotoxicity in breast cancer survivors by improving antioxidant capacity and reducing oxidative stress, though further clinical research is needed to establish optimal dosing and efficacy.

Limitations

  • Further clinical research is needed to determine feasibility, effectiveness, applicable cancer therapies, and optimal exercise dose.
  • Further clinical research is needed to determine feasibility and effectiveness
  • Need to identify specific cancer therapies for which exercise is effective
  • Optimal exercise dose remains to be determined

Cite This Study

Kirkham et al. (2015) conducted a review in Breast cancer with risk of cardiovascular disease. Exercise was evaluated. Exercise appears to protect against chemotherapy-associated cardiovascular toxicity in breast cancer survivors by improving antioxidant capacity and reducing oxidative stress.

synapsesocial.com/papers/6a208ae1f9c5f638e0cc4298https://doi.org/10.1155/2015/917606
View Full Paper
Ask AI
Bookmark
Share