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July 2, 1983European Heart Journal

All beta blockers significantly reduced HR, CO, and BP at rest and exercise; CO and HR decreased by 20-25% on beta blockers without ISA, with less reduction on those with strong ISA, while TPR was not significantly reduced below pre-treatment levels.

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Why the study?

Do different beta blockers have varying central haemodynamic effects during chronic treatment in patients with hypertension?

Population

Patients with hypertension

Comparison

Chronic treatment with various beta blockers or… vs Pre-treatment baseline

Design

Cohort

Follow-up

1 year

Authors

PLPer Lund‐Johansen

Discussion

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Overview

Supports ISA-based beta blocker selection in hypertension; extends haemodynamic data but leaves outcome effects open.

Key Points

  • To investigate the chronic haemodynamic effects of seven beta blockers on hypertension over one year.
  • Studied seven beta blockers: atenolol, metoprolol, timolol, penbutolol, alprenolol, pindolol, and bunitrolol over one year.
  • Measured heart rate, cardiac output, and blood pressure at rest and during exercise.
  • Analyzed total peripheral resistance changes in response to beta blockers with and without intrinsic sympathomimetic activity.
  • All beta blockers significantly reduced heart rate, cardiac output, and blood pressure at rest and during exercise.
  • Cardiac output and heart rate decreased by 20-25% during 100 and 150 W exercise for beta blockers without ISA.
  • No beta blocker significantly reduced total peripheral resistance below pre-treatment levels at rest or during exercise.

Structured PICO

Do different beta blockers have varying central haemodynamic effects during chronic treatment in patients with hypertension?

P
Population
Patients with hypertension
I
Intervention
Chronic treatment (one year) with various beta blockers (atenolol, metoprolol, timolol, penbutolol, bunitrolol, alprenolol, pindolol) or combined alpha/beta blockers (prizidilol, labetalol)
C
Comparator
Pre-treatment baseline
O
Outcome
Changes in heart rate (HR), cardiac output (CO), blood pressure (BP), and total peripheral resistance (TPR) at rest and during exercisesurrogate

Chronic treatment with various beta blockers consistently reduces heart rate, cardiac output, and blood pressure in hypertensive patients, with the magnitude of reduction depending on intrinsic sympathomimetic activity (ISA).

Cite This Study

Per Lund‐Johansen (1983) studied this question.

synapsesocial.com/papers/6a213c0fd96c1a33c45acd1fhttps://doi.org/10.1093/eurheartj/4.suppl_d.1
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