January 1, 1985Heart51 citationsOpen Access
Prognostic significance of left ventricular ejection fraction after acute myocardial infarction. A bedside radionuclide study.
Key Result
Left ventricular ejection fraction <0.35 measured within 24 hours of acute myocardial infarction predicted all in-hospital ventricular fibrillation and pump failure deaths, and 12 of 13 later deaths.
Study Design
Type
Cohort (n=171)
Structured PICO
Does left ventricular ejection fraction < 0.35 measured within 24 hours of acute myocardial infarction predict ventricular fibrillation and mortality?
P
Population
171 patients assessed within a mean of 24 hours after acute myocardial infarction, followed for a mean of 15 months.
E
Exposure
Left ventricular ejection fraction < 0.35 measured with a radionuclide first pass portable probe method within a mean of 24 hours of symptom onset
C
Comparator
Left ventricular ejection fraction ≥ 0.35
O
Outcome
Incidence of ventricular fibrillation in hospital, hospital deaths due to pump failure, and postdischarge deathshard clinical
Bedside measurement of LVEF within 24 hours of acute myocardial infarction strongly predicts in-hospital ventricular fibrillation and mortality over the subsequent year.
Abstract
The prognostic significance of left ventricular ejection fraction measurements obtained at the bedside was assessed in 171 patients as soon as possible after acute myocardial infarction. Ejection fraction was measured with a radionuclide first pass portable probe method within a mean of 24 hours of the onset of major symptoms. The results were related prospectively to the subsequent incidence of ventricular fibrillation in hospital, and to hospital and postdischarge deaths in a mean follow up period of 15 (range 9-21) months. All eight episodes of primary ventricular fibrillation, all 12 deaths due to pump failure in hospital, and also 12 out of 13 postdischarge deaths occurred in that minority of 81 patients whose initial postinfarction left ventricular ejection fraction was less than 0.35. Multivariate correlation with clinical, enzymatic, and electrocardiographic indicators of myocardial infarction showed that the prognostic significance of these indicators could largely be explained by their association with low left ventricular ejection fractions. Left ventricular ejection fraction measured within the initial 24 hours after acute myocardial infarction predicts prognosis throughout the subsequent year.
Cite This Study
Kelly et al. (1985) conducted a cohort in acute myocardial infarction (n=171). Left ventricular ejection fraction < 0.35 vs. Left ventricular ejection fraction ≥ 0.35 was evaluated on ventricular fibrillation in hospital, and hospital and postdischarge deaths. Left ventricular ejection fraction <0.35 measured within 24 hours of acute myocardial infarction predicted all in-hospital ventricular fibrillation and pump failure deaths, and 12 of 13 later deaths.