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August 1, 1975Biochemical JournalOpen Access

The distribution and partial characterization of the serum apolipoproteins in the guinea pig

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Population

Male guinea pigs fed on a diet containing 3-4% fat

Design

Preclinical

Authors

MCM. John ChapmanGMG.L. MillsJLJoanna H. Ledford

Discussion

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Overview

Guinea pig data warrant no clinical translation yet; leaves open validation as human lipoprotein models.

Structured PICO

P
Population
Male guinea pigs fed on a diet containing 3-4% fat
I
Intervention
Isolation and characterization of very-low-density (VLD), low-density (LD), and high-density (HD) lipoproteins and their apoproteins
O
Outcome
Distribution and physicochemical properties of serum apolipoproteinssurrogate

This study characterizes the apolipoprotein profile of guinea pigs, demonstrating similarities to human apolipoproteins B, A-I, and C-I, which may inform their use as an animal model for lipid research.

Cite This Study

Chapman et al. (1975) studied this question.

synapsesocial.com/papers/6a2272c3ac77194489b71100https://doi.org/10.1042/bj1490423
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