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July 1, 1993Journal of VirologyOpen Access

Molecular characterization of mouse-virulent poliovirus type 1 Mahoney mutants: involvement of residues of polypeptides VP1 and VP2 located on the inner surface of the capsid protein shell

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Population

Mice inoculated with poliovirus type 1 Mahoney mutants

Comparison

Single amino acid substitutions in capsid… vs Parental mouse-avirulent PV-1/Mahoney

Design

Preclinical

Key result

Single amino acid substitutions in the inner surface of capsid proteins VP1 (Thr-22-->Ile) and VP2 (Ser-31-->Thr) conferred a mouse-virulent phenotype to the mouse-avirulent PV-1/Mahoney virus.

Authors

TCThérèse CoudercJHJames M. HogleHBH Le Blay

Discussion

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Overview

Identifies novel poliovirus adaptation determinants in mice; leaves open relevance to human neurovirulence and attenuation.

Structured PICO

P
Population
Mice inoculated with poliovirus type 1 Mahoney mutants
I
Intervention
Single amino acid substitutions in capsid proteins VP1 (Thr-22-->Ile) and VP2 (Ser-31-->Thr)
C
Comparator
Parental mouse-avirulent PV-1/Mahoney
O
Outcome
Neurovirulence in micesurrogate

Single amino acid substitutions on the inner surface of the capsid protein shell (VP1 and VP2) are determinants for mouse neurovirulence in poliovirus type 1.

Cite This Study

Couderc et al. (1993) studied Poliovirus infection. Single amino acid substitutions in capsid proteins VP1 (Thr-22-->Ile) and VP2 (Ser-31-->Thr) vs. Parental mouse-avirulent PV-1/Mahoney virus was evaluated on Mouse neurovirulence. Single amino acid substitutions in the inner surface of capsid proteins VP1 (Thr-22-->Ile) and VP2 (Ser-31-->Thr) conferred a mouse-virulent phenotype to the mouse-avirulent PV-1/Mahoney virus.

synapsesocial.com/papers/6a22c13904258437f814c4c6https://doi.org/10.1128/jvi.67.7.3808-3817.1993
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