This review summarizes the current understanding of the poliovirus and human poliovirus receptor interaction at the genetic and biochemical level, including implications for tissue tropism.
The ability of a virus to attach to a susceptible host cell is of utmost importance for the initiation of viral life cycle. Cell surface proteins called viral receptors mediate the initial steps of virus attachment and uptake. Poliovirus (PV) is one of the most studied animal viruses and its interaction with its cellular receptor, the human poliovirus receptor (hPVR) has been well characterized. This review will present our current understanding of the PV/hPVR interaction at the genetic and biochemical level. In addition, we will also discuss the implications of the PV/hPVR interaction on PV tissue tropism and the evolution of the three PV serotypes.
Solecki et al. (1998) conducted a review in Poliovirus infection. Poliovirus/human poliovirus receptor (hPVR) interaction was evaluated. This review summarizes the current understanding of the poliovirus and human poliovirus receptor interaction at the genetic and biochemical level, including implications for tissue tropism.