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December 1, 1961Science114 citations

Glucose-6-Phosphate Dehydrogenase and Detoxification of Hydrogen Peroxide in Human Erythrocytes

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GCGerald CohenBronx-Lebanon Hospital CenterPHPaul HochsteinUniversity of Southern California

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Abstract

Human erythrocytes with deficient glucose-6-phosphate dehydrogenase levels are unable to maintain their levels of reduced glutathione in the presence of low-level, steady-state concentrations of hydrogen peroxide. This finding has bearing on the biochemical mechanisms of drug-induced hemolytic anemia.

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Cite This Study

Cohen et al. (1961) studied this question.

synapsesocial.com/papers/6a719052ce524a4339c50999https://doi.org/10.1126/science.134.3492.1756
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