Are plasma endothelinlike immunoreactivity levels elevated in IDDM patients with microalbuminuria compared to normoalbuminuric patients and controls?
Elevated plasma endothelin levels in IDDM patients with microalbuminuria suggest a role for endothelial dysfunction in diabetic vascular disease.
OBJECTIVE: To determine whether plasma endothelin, a potent vasoconstrictor and growth factor for vascular smooth muscle, is elevated in microalbuminuric insulin-dependent diabetes mellitus patients. RESEARCH DESIGN AND METHODS: Plasma endothelinlike immunoreactivity was measured by radioimmunoassay in 15 microalbuminuric diabetic patients, 12 normoalbuminuric diabetic patients, and 12 control subjects. RESULTS: The mean levels of plasma endothelinlike immunoreactivity were raised in the normoalbuminuric patients (8.4 pM range 4.8-12.7 pM; P less than 0.01) and the microalbuminuric patients (10.2 pM range 5.6-31.1 pM; P less than 0.001) compared with control subjects (6.1 pM range 4.5-7.6 pM). Plasma endothelinlike immunoreactivity was also higher in the microalbuminuric patients compared with the normoalbuminuric patients (P less than 0.05). CONCLUSIONS: The increase in plasma endothelinlike immunoreactivity further confirms endothelial dysfunction in diabetes and this increase in plasma endothelin may contribute to the vascular disease prevalent in diabetes.
Collier et al. (1992) studied this question.