October 1, 2007Journal of Clinical Hypertension74 citationsOpen Access
Differential Impacts of Adiponectin on Low‐Grade Albuminuria Between Obese and Nonobese Persons Without Diabetes
Structured PICO
P
Population
157 nondiabetic adults from a rural community in Japan, mean age 60.7 years, 46% male. Key exclusions: diabetes mellitus (fasting glucose ≥126 mg/dL or on therapy) and macroalbuminuria (UAE ≥200 mg/min).
O
Outcome
Urinary albumin excretion (UAE) assessed by overnight collectionsurrogate
Adiponectin levels are inversely associated with low-grade albuminuria in obese nondiabetic individuals, suggesting a potential protective role against early obesity-related vascular injury.
Limitations
- Cross-sectional study design cannot prove cause-effect relationship
- Only persons of Japanese ethnicity studied with BMI cutoff of 25 kg/m2, limiting generalizability to other ethnicities
- Voluntary participation may introduce healthy worker effect bias
- Lack of data on the specific class of antihypertensive medications participants were taking
Abstract
The goal of this study was to examine the association between adiponectin and low-grade albuminuria in nondiabetic persons and whether it differed between obese and nonobese individuals. Urinary albumin excretion (UAE) was assessed by overnight collection in 157 participants. Overall, as anticipated, 24-hour systolic blood pressure and fasting glucose levels were independent determinants of UAE (beta=0.254 and 0.176, respectively, P/=25 kg/m(2); n=63), adiponectin value was a significant negative determinant of UAE (beta=-0.256, P<.05) independent of blood pressure and glucose levels, whereas in nonobese participants (n=94) it was not. In an analysis of BMI and the median value of adiponectin (9.9 microg/mL), UAE was found to be significantly higher in obese persons with low adiponectin levels than in obese persons with high adiponectin levels (9.20 vs 5.11 microg/min; P<.05), even after adjustment for age, sex, blood pressure level, and glucose level. There was an inverse association between adiponectin and low-grade albuminuria in obese nondiabetic persons.
Cite This Study
Yano et al. (2007) studied this question.