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October 18, 2007Organic Letters71 citations

Gold(I)-Catalyzed Three-Component Additions of 2-(Arylmethylene)cyclopropylcarbinols, Terminal Arynes, and Alcohols: An Efficient Access to 3-Oxabicyclo3.1.0hexanes

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GTGuoqiang TianMSMin Shi

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Abstract

Catalyzed by gold(I), (E)- and (Z)-2-(arylmethylene)cyclopropylcarbinols, terminal arynes, and alcohols underwent three-component addition reactions to produce 3-oxabicyclo3.1.0hexanes in high yields and moderate diastereoselectivities under mild conditions. A plausible mechanism based on an intermolecular tandem hydroalkoxylation/Prins-type reaction pathway has been proposed.

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Cite This Study

Tian et al. (2007) studied this question.

synapsesocial.com/papers/6a98772ce69854433b9fb507https://doi.org/10.1021/ol702341a
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