Review reveals the complex effects of reactive oxygen species on cancer signaling pathways, suggesting new therapeutic strategies for targeting redox dynamics in tumors.
Key Points
Reactive oxygen species can promote or inhibit cancer progression depending on their concentration and context.
ROS regulation affects key signaling pathways like PI3K/Akt and NF-κB, influencing tumor responses and immune interactions.
Research highlights the role of ROS-generating enzymes in shaping the tumor microenvironment and modulating immune responses.
Advancements in redox biosensors and targeting strategies offer new approaches to improve therapeutic outcomes in cancer treatment.