July 31, 2025

The global, regional, national burden of laryngeal cancer in young males and its attributable risk factors (1990–2021) and predictions to 2035

Key Points

Laryngeal cancer incidence in young males exceeded 2,399 cases in 2021, with age-standardised rates of 0.16.
Deaths from laryngeal cancer in this group reached 1,256 in 2021, showing an age-standardised rate of 0.08.
The burden included over 71,192 disability-adjusted life years, with an ASR of 4.72 in the same year.
Future projections indicate a decline in age-standardised incidence rates, highlighting the need for prevention strategies targeting young males.

Abstract

Abstract Objective: We aim to report the incidence, mortality and disability-adjusted life years (DALYs) between 1990 and 2021 and provide predictions to 2035. Methods: We use estimates from Global Burden of Disease, Injuries and Risk Factors Study 2021 to analyse the incidence, mortality and DALYs. Results: In 2021, there were more than 2,399.19 incidence cases, with age-standardised rates (ASRs) of 0.16. Laryngeal cancer in young men accounted for 1,256.72 death cases, with ASRs of 0.08. Laryngeal cancer was also responsible for 71,192.43(64,067.23 to 80,489.33) DALYs, with ASRs of 4.72 (4.24 to 5.33). In 2021, Eastern Europe had the highest age-standardised incidence rate. At the national level, the highest incidence rate was observed in Monaco. Deathss were attributable to Tobacco, High alcohol use and Occupational risks.The age-standardised incidence rate in global is projected to decrease between 2021 and 2035. Conclusions: Despite the current and predicted decline in age-standardised incidence of Laryngeal cancer in young males globally, the absolute number of estimates continue to increase. Prevention programmes should concentrate on modifiable risk factors, especially among the males aged 35-39.

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