Significance: Stress represents a key contributor to internalizing disorders and of rising global mental health challenges, particularly in young individuals. There is a critical need for accessible, brain– based interventions that can strengthen stress regulation and promote resilience. Aim: We investigated whether a single session of real–time functional near–infrared spectroscopy (fNIRS)–informed neurofeedback training targeting the lateral prefrontal cortex (PFC) can enhance stress regulation under ecologically valid physiological and social stress conditions. Approach: In a pre–registered double–blind, sham–controlled parallel–group trial, 60 young healthy adults underwent four neurofeedback, preceded and followed by baseline and maintenance runs without feedback. The training combined continuous feedback from individualized lateral PFC channels with reappraisal strategies to guide regulatory control. Stress regulation was assessed using the socially–evaluated cold pressor test (SECPT) that combines physiological and social stressors. Results: Neurofeedback significantly increased lateral PFC activity across training runs. Participants in the neurofeedback group exhibited reduced stress – but not pain – experience in the SECPT and post–training anxiety, reflecting a successful domain–specific transfer of regulatory control. Conclusions: This study demonstrates fNIRS–guided PFC neurofeedback facilitates adaptive learning of regulatory control and robustly enhances stress regulation and resilience under real–world stress. This scalable, non–invasive intervention offers a promising translational strategy for promoting resilience in vulnerable populations.
Tsang et al. (Tue,) studied this question.